|
KMID : 0369819900200030129
|
|
Jorunal of Korean Pharmaceutical Sciences
1990 Volume.20 No. 3 p.129 ~ p.134
|
|
|
Preparation and Dissolution Properties of Ftorafur - Galatin Microcapsules
|
|
이수정/Lee SJ
김길수/Kim KS
|
|
|
Abstract
|
|
|
|
Gelatin microcapsules containing Ftorafur, a hydrophilic anticancer agent, were prepared with congealable disperse-phase emulsification method. The preparation was based on dispersion of ftorafur-gelatin solution with Tween #40 or Span #20 in liquid paraffin. A cationic surfactant, benzethonium chloride, was used to prevent the microcapsules from aggregation. In the case of microcapsules prepared with Tween #40 or Span #20, mean particle size decreased and narrow size distribution was observed. The intrinsic dissolution rate of ftorafur in microcapsules with 1% span #20 was 8.5 times lower than that of intact ftorafur.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|